Continuous-flow left ventricular assist devices induce left ventricular reverse remodeling

Continuous-flow left ventricular assist devices induce left ventricular reverse remodeling.

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Left ventricular assist device-induced reverse ventricular remodeling.

Left ventricular assist devices provide chronic pressure and volume unloading of the dilated left ventricle in patients with end-stage heart failure. This is associated with reverse structural remodeling (normalization of the passive pressure-volume relationship), reverse molecular remodeling (increased expression of several genes involved in calcium metabolism that are down-regulated in heart ...

Left Ventricular Assist Devices.

Gastrointestinal bleeding with continuous-flow left ventricular assist devices.

Continuous-flow left ventricular assist device (CF-LVAD) insertion is a life-saving procedure that is being increasingly used in patients with advanced heart failure. However, patients with CF-LVADs are at an increased risk of gastrointestinal bleeding (GIB). Bleeding can occur anywhere in the GI tract with lesions being more prevalent in the upper GI tract than in the lower GI tract. The patho...

Effects of continuous-flow versus pulsatile-flow left ventricular assist devices on myocardial unloading and remodeling.

BACKGROUND Continuous-flow left ventricular assist devices (LVAD) are increasingly used for patients with end-stage heart failure (HF). We analyzed the effects of ventricular decompression by continuous-flow versus pulsatile-flow LVADs on myocardial structure and function in this population. METHODS AND RESULTS Sixty-one patients who underwent LVAD implantation as bridge-to-transplant were an...